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The JBJS Quiz of the Month is a collection of 10 relevant questions from each orthopaedic subspecialty. The questions are drawn from JBJS Clinical Classroom, which houses over 4,500 questions and 3,100 learning resources. Take the Quiz to see how you score against your peers!

NOTE: This quiz does not earn users CME credits. The questions must be answered within Clinical Classroom to earn CME credits.

The gastrointestinal tract microbiome has been implicated in the pathogenesis of osteoporosis through which of the following mechanisms?

    • Impacts serum vitamin D levels
      • The microbiome has been hypothesized to play a role in vitamin D absorption; however, studies have been unable to demonstrate a clear association.

 

    • Inhibits osteoclastic activity
      • Although it may play a role in osteoclastic activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoclastic activity.

 

    • Enhances osteoblast activity
      • Although it may play a role in regulating osteoblast activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoblast activity.

 

    • Influences absorption of calcium from the digestive tract
      • Variation in the microbiome influences the uptake of calcium from the gastrointestinal tract, which may impact the development of osteoporosis.

     

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