The JBJS Quiz of the Month is a collection of 10 relevant questions from each orthopaedic subspecialty. The questions are drawn from JBJS Clinical Classroom, which houses over 4,500 questions and 3,100 learning resources. Take the Quiz to see how you score against your peers!

NOTE: This quiz does not earn users CME credits. The questions must be answered within Clinical Classroom to earn CME credits.

A patient undergoing orthopaedic surgery experiences acute decompensation intra-operatively that is mitigated with hyperoxygenation and serial injections of dantrolene. Susceptibility to which of the following conditions may be identified in this patient’s family?

    • Malignant hyperthermia
    • Malignant hyperthermia (MH) is a potentially fatal condition that occurs in susceptible individuals with an autosomal dominantly inherited mutation in skeletal muscle ryanodine receptors.


    • Fat embolism syndrome
    • Fat embolism syndrome (FES) is treated with supportive care that includes respiratory support, but dantrolene has no role in FES.


    • Lidocaine toxicity
    • Toxicities from local anesthetics, especially cardiac events, are treated with infusion of lipid emulsion.


    • Ischemia/reperfusion injury
    • Dantrolene has been sparsely studied in ischemia/reperfusion injuries to tissues other than skeletal muscle, but family history would not be contributory to ischemia/reperfusion injury.