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The gastrointestinal tract microbiome has been implicated in the pathogenesis of osteoporosis through which of the following mechanisms? |
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- Impacts serum vitamin D levels The microbiome has been hypothesized to play a role in vitamin D absorption; however, studies have been unable to demonstrate a clear association.
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- Inhibits osteoclastic activity Although it may play a role in osteoclastic activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoclastic activity.
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- Enhances osteoblast activity Although it may play a role in regulating osteoblast activity, studies have not demonstrated a role for the microbiome in direct regulation of osteoblast activity.
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- Influences absorption of calcium from the digestive tract Variation in the microbiome influences the uptake of calcium from the gastrointestinal tract, which may impact the development of osteoporosis.
